Article
Pyrosequencing of the CYP2C9 -1766T>C polymorphism as a means of detecting the CYP2C9*8 allele.
Pharmacogenomics - 1 Sept 2014
Patel Shitalben R, Langaee Taimour Y, Wong Shan S, Cavallari Larisa H
Abstract excerpt
The CYP2C9 c.449G>A (p.R150H, rs7900194) polymorphism, which confers the CYP2C9*8 allele, is common in persons of African descent and results in reduced clearance of the narrow therapeutic index drugs, warfarin and phenytoin. Because of significant homology in DNA sequence at the 449G>A locus among CYP2C genes, the 449G>A variant cannot be reliably detected via PCR-based genotyping assays that require a short PCR...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.