Rapid single-nucleotide polymorphism detection of cytochrome P450 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genes for the warfarin dose adjustment by the SMart-amplification process version 2.

doi:10.1373/clinchem.2008.115295

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Rapid single-nucleotide polymorphism detection of cytochrome P450 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genes for the warfarin dose adjustment by the SMart-amplification process version 2.

Clinical chemistry - 1 Apr 2009

Aomori Tohru, Yamamoto Koujirou, Oguchi-Katayama Atsuko, Kawai Yuki, Ishidao Takefumi, Mitani Yasumasa, Kogo Yasushi, Lezhava Alexander, Fujita Yukiyoshi, Obayashi Kyoko, Nakamura Katsunori, Kohnke Hugo, Wadelius Mia, Ekström Lena, Skogastierna Cristine, Rane Anders, Kurabayashi Masahiko, Murakami Masami, Cizdziel Paul E, Hayashizaki Yoshihide, Horiuchi Ryuya

Abstract excerpt

BACKGROUND: Polymorphisms of the CYP2C9 (cytochrome P450, family 2, subfamily C, polypeptide 9) gene (CYP2C9*2, CYP2C9*3) and the VKORC1 (vitamin K epoxide reductase complex, subunit 1) gene (-1639G>A) greatly impact the maintenance dose for the drug warfarin. Prescreening patients for their genotypes before prescribing the drug facilitates a faster individualized determination of the proper maintenance dose,...

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PMID: 19181737
DOI: 10.1373/clinchem.2008.115295

Genes

VKORC1

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Rapid single-nucleotide polymorphism detection of cytochrome P450 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genes for the warfarin dose adjustment by the SMart-amplification process version 2.PMID 19181737Read ↗

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