Cytochrome P4502C9 (CYP2C9) allele frequencies in Canadian Native Indian and Inuit populations.

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Article

Cytochrome P4502C9 (CYP2C9) allele frequencies in Canadian Native Indian and Inuit populations.

Canadian journal of physiology and pharmacology - 1 Oct 2001

Gaedigk A, Casley W L, Tyndale R F, Sellers E M, Jurima-Romet M, Leeder J S

Abstract excerpt

CYP2C9 is the major P450 2C enzyme in human liver and contributes to the metabolism of a number of clinically important substrate drugs. This polymorphically expressed enzyme has been studied in Caucasian, Asian, and to some extent in African American populations, but little is known about the genetic variation in Native American populations. We therefore determined the 2C9*2 (Arg144Cys) and 2C9*3 (Ile359Leu)...

Topics

Alleles
Aryl Hydrocarbon Hydroxylases
Asian
Canada
China
Cytochrome P-450 CYP2C9
Cytochrome P-450 Enzyme System
DNA
Gene Frequency
Genotype
Humans
Indians, North American
Inuit
Polymorphism, Genetic
Steroid 16-alpha-Hydroxylase
Steroid Hydroxylases

Source

Open in PubMed

Identifiers

PMID: 11697742

Provenance

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