Article
Immune response to Candida albicans is preserved despite defect in O-mannosylation of secretory proteins.
Medical mycology - 1 Dec 2007
Corbucci Cristina, Cenci Elio, Skrzypek Franck, Gabrielli Elena, Mosci Paolo, Ernst Joachim F, Bistoni Francesco, Vecchiarelli Anna
Abstract excerpt
The PMT gene family in Candida albicans encodes five isoforms of the protein mannosyltransferases that initiate O-mannosylation of secretory proteins. Mutations at the Pmt level have been associated with differences in pathogenicity, e.g. in contrast to pmt5/pmt5, pmt2/PMT2 mutants showed poor virulence. Our objective was to determine whether these differences were related to the capacity of pmt2/PMT2 and...
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