Article
Role of protein O-mannosyltransferase Pmt4 in the morphogenesis and virulence of Cryptococcus neoformans.
Eukaryotic cell - 1 Feb 2007
Olson Gillian M, Fox Deborah S, Wang Ping, Alspaugh J Andrew, Buchanan Kent L
Abstract excerpt
Protein O mannosylation is initiated in the endoplasmic reticulum by protein O-mannosyltransferases (Pmt proteins) and plays an important role in the secretion, localization, and function of many proteins, as well as in cell wall integrity and morphogenesis in fungi. Three Pmt proteins, each belonging to one of the three respective Pmt subfamilies, are encoded in the genome of the human fungal pathogen...
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