Article
A multifunctional mannosyltransferase family in Candida albicans determines cell wall mannan structure and host-fungus interactions.
The Journal of biological chemistry - 16 Apr 2010
Mora-Montes Héctor M, Bates Steven, Netea Mihai G, Castillo Luis, Brand Alexandra, Buurman Ed T, Díaz-Jiménez Diana F, Jan Kullberg Bart, Brown Alistair J P, Odds Frank C, Gow Neil A R
Abstract excerpt
The cell wall proteins of fungi are modified by N- and O-linked mannosylation and phosphomannosylation, resulting in changes to the physical and immunological properties of the cell. Glycosylation of cell wall proteins involves the activities of families of endoplasmic reticulum and Golgi-located glycosyl transferases whose activities are difficult to infer through bioinformatics. The Candida albicans MNT1/KRE2...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.