Article
Members of protein O-mannosyltransferase family in Aspergillus fumigatus differentially affect growth, morphogenesis and viability.
Molecular microbiology - 1 Jun 2010
Mouyna Isabelle, Kniemeyer Olaf, Jank Thomas, Loussert Céline, Mellado Emilia, Aimanianda Vishukumar, Beauvais Anne, Wartenberg Dirk, Sarfati Jacqueline, Bayry Jagadeesh, Prévost Marie-Christine, Brakhage Axel A, Strahl Sabine, Huerre Michel, Latgé Jean-Paul
Abstract excerpt
O-mannosylation is an essential protein modification in eukaryotes. It is initiated at the endoplasmic reticulum by O-mannosyltransferases (PMT) that are evolutionary conserved from yeast to humans. The PMT family is phylogenetically classified into PMT1, PMT2 and PMT4 subfamilies, which differ in protein substrate specificity and number of genes per subfamily. In this study, we characterized for the first time...
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