Article
O-Mannosyltransferase 1 in Aspergillus fumigatus (AfPmt1p) is crucial for cell wall integrity and conidium morphology, especially at an elevated temperature.
Eukaryotic cell - 1 Dec 2007
Zhou Hui, Hu Hongyan, Zhang Lijuan, Li Ruoyu, Ouyang Haomiao, Ming Jia, Jin Cheng
Abstract excerpt
Protein O-mannosyltransferases initiate O mannosylation of secretory proteins, which are of fundamental importance in eukaryotes. In this study, the PMT gene family of the human fungal pathogen Aspergillus fumigatus was identified and characterized. Unlike the case in Saccharomyces cerevisiae, where the PMT family is highly redundant, only one member of each PMT subfamily, namely, Afpmt1, Afpmt2, and Afpmt4, is...
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