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Article

Protein O-mannosyltransferase isoforms regulate biofilm formation in Candida albicans.

Antimicrobial agents and chemotherapy - 1 Oct 2006

Peltroche-Llacsahuanga Heidrun, Goyard Sophie, d'Enfert Christophe, Prill Stephan K-H, Ernst Joachim F

Abstract excerpt

Five isoforms of protein mannosyltransferase (Pmt) O-mannosylate secretory proteins in Candida albicans. pmt mutants were differentially defective for biofilm formation on plastic in static and flow-through systems, and a Pmt inhibitor blocked early stages of biofilm formation. Conceptually, Pmt inhibition may prevent surface anchoring and biofilm-dependent resistance of fungal pathogens.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17005840
DOI: 10.1128/AAC.00606-06
PMCID: PMC1610076

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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