Article
Multiple functions of Pmt1p-mediated protein O-mannosylation in the fungal pathogen Candida albicans.
The Journal of biological chemistry - 14 Aug 1998
Timpel C, Strahl-Bolsinger S, Ziegelbauer K, Ernst J F
Abstract excerpt
Protein mannosylation by Pmt proteins initiates O-glycosylation in fungi. We have identified the PMT1 gene and analyzed the function of Pmt1p in the fungal human pathogen Candida albicans. Mutants defective in PMT1 alleles lacked Pmt in vitro enzymatic activity, showed reduced growth rates, and t...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Candida albicans
- DNA Primers
- Fungal Proteins
- Genetic Complementation Test
- Humans
- Male
- Mannose
- Mannosyltransferases
- Mice
- Molecular Sequence Data
- Mutation
- Sequence Homology, Amino Acid
- Tumor Cells, Cultured
- Virulence