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Pharmacokinetic and pharmacodynamic basis for partial protection against alcoholism in Asians, heterozygous for the variant ALDH2*2 gene allele.

Pharmacogenetics and genomics - 1 Oct 2007

Peng Giia-Sheun, Chen Yi-Chyan, Tsao Tien-Ping, Wang Ming-Fang, Yin Shih-Jiun

Abstract excerpt

OBJECTIVES: It has been well documented that although homozygosity of the variant aldehyde dehydrogenase-2 (ALDH2) gene allele, ALDH2*2, in Asians almost fully protects against alcoholism, the heterozygosity only affords a partial protection to varying degrees. The full protection against alcoholism has been ascribed to the low-amount of alcohol hypersensitivity accompanied by a prolonged and large accumulation...

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Source

Identifiers

PMID: 17885622
DOI: 10.1097/FPC.0b013e3282609e67

Genes

ALDH2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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