Article
Alcohol sensitivity in Taiwanese men with different alcohol and aldehyde dehydrogenase genotypes.
Journal of the Formosan Medical Association = Taiwan yi zhi - 1 Nov 2002
Peng Giia-Sheun, Yin Jiu-Haw, Wang Ming-Fang, Lee Jiuun-Tay, Hsu Yaw-Don, Yin Shih-Jiun
Abstract excerpt
BACKGROUND AND PURPOSE: Previous studies demonstrated that ADH2*2, encoding for high-maximal velocity (Vmax) beta2-alcohol dehydrogenase (ADH) activity, and mutant ALDH2*2, encoding for null aldehyde dehydrogenase (ALDH) 2 activity, independently influence susceptibility to alcoholism. A single copy of the ALDH2*2 allele may protect less strongly than a single copy of ADH2*2 in individuals carrying only one copy...
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