Strong protective effect of the aldehyde dehydrogenase gene (ALDH2) 504lys (*2) allele against alcoholism and alcohol-induced medical diseases in Asians.

doi:10.1007/s00439-011-1116-4

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Article

Strong protective effect of the aldehyde dehydrogenase gene (ALDH2) 504lys (*2) allele against alcoholism and alcohol-induced medical diseases in Asians.

Human genetics - 1 May 2012

Li Dawei, Zhao Hongyu, Gelernter Joel

Abstract excerpt

Alcohol is oxidized to acetaldehyde, which in turn is oxidized to acetate. The aldehyde dehydrogenase 2 gene (ALDH2) is the most important gene responsible for acetaldehyde metabolism. Individuals heterozygous or homozygous for the lys (A or *2) allele at the single nucleotide polymorphism (SNP) glu504lys (rs671) of ALDH2 have greatly reduced ability to metabolize acetaldehyde, which greatly decreases their risk...

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Identifiers

PMID: 22102315
DOI: 10.1007/s00439-011-1116-4
PMCID: PMC3548401

Genes

ALDH2

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