Pharmacokinetic and pharmacodynamic basis for overcoming acetaldehyde-induced adverse reaction in Asian alcoholics, heterozygous for the variant ALDH2*2 gene allele.

Abstract excerpt

OBJECTIVES: It has been well documented that although homozygosity of the variant aldehyde dehydrogenese-2 (ALDH2) gene allele, ALDH2*2, in Asians almost fully protects against alcoholism, the heterozygosity only affords a partial protection to varying degrees. The partial protection against alcoholism has been ascribed to the faster elimination of acetaldehyde by residual hepatic ALDH2 activity and the lower...

Topics

• Acetaldehyde
• Adult
• Alcoholism
• Aldehyde Dehydrogenase
• Aldehyde Dehydrogenase, Mitochondrial
• Alleles
• Asian People
• China
• Ethanol
• Genetic Variation
• Genotype