Article
The presence of the Trim5alpha escape mutation H87Q in the capsid of late stage HIV-1 variants is preceded by a prolonged asymptomatic infection phase.
AIDS (London, England) - 1 Oct 2007
Kootstra Neeltje A, Navis Marjon, Beugeling Corrine, van Dort Karel A, Schuitemaker Hanneke
Abstract excerpt
BACKGROUND: Recently, the tripartite interaction motif 5alpha (Trim5alpha) has been identified as an inhibitory factor blocking infection of a broad range of retroviruses in a species-specific manner. In particular, HIV-1 replication can be efficiently blocked by Trim5alpha from Old World monkeys. The cyclophilin A binding region in the HIV-1 capsid is believed to be the viral determinant for Trim5alpha, and...
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