Article
The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys.
Nature - 26 Feb 2004
Stremlau Matthew, Owens Christopher M, Perron Michel J, Kiessling Michael, Autissier Patrick, Sodroski Joseph
Abstract excerpt
Host cell barriers to the early phase of immunodeficiency virus replication explain the current distribution of these viruses among human and non-human primate species. Human immunodeficiency virus type 1 (HIV-1), the cause of acquired immunodeficiency syndrome (AIDS) in humans, efficiently enters the cells of Old World monkeys but encounters a block before reverse transcription. This species-specific restriction...
Topics
- Amino Acid Sequence
- Animals
- Cell Line
- Cloning, Molecular
- Cytoplasmic Structures
- Disease Susceptibility
- Genetic Variation
- HIV Infections
- HIV-1
- HeLa Cells
- Humans
- Macaca mulatta
- Molecular Sequence Data
- Mutation