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Article

Role of common human TRIM5alpha variants in HIV-1 disease progression.

Retrovirology - 22 Aug 2006

Goldschmidt Valérie, Bleiber Gabriela, May Margaret, Martinez Raquel, Ortiz Millàn, Telenti Amalio

Abstract excerpt

BACKGROUND: The retroviral restriction factor tripartite motif protein (TRIM)5alpha, is characterized by marked amino acid diversity among primates, including specific clusters of residues under positive selection. The identification of multiple non-synonymous changes in humans suggests that TRIM5alpha variants might be relevant to retroviral pathogenesis. Previous studies have shown that such variants are...

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Identifiers

PMID: 16925802
DOI: 10.1186/1742-4690-3-54
PMCID: PMC1560158

Genes

TRIM5

Provenance

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Role of common human TRIM5alpha variants in HIV-1 disease progression.PMID 16925802Read ↗

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