Strain-specific differences in the impact of human TRIM5alpha, different TRIM5alpha alleles, and the inhibition of capsid-cyclophilin A interactions on the infectivity of HIV-1.

Abstract excerpt

HIV-1 infectivity is strongly restricted by TRIM5α from certain primate species but has been described as being only marginally susceptible to human TRIM5α. In this study, we evaluated the effects of the modulation of human TRIM5α activity (pretreatment of target cells with alpha interferon, expression of a pre-miRNA targeting TRIM5α, and/or overexpression of TRIM5γ), the inhibition of cyclophilin A (CypA)-CA...

Topics

• Alleles
• Antiviral Restriction Factors
• Base Sequence
• Capsid
• Carrier Proteins
• Cyclophilin A
• Gene Products, gag
• HIV-1
• Humans
• Species Specificity
• Tripartite Motif Proteins