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Article

The mitotic regulator Survivin binds as a monomer to its functional interactor Borealin.

The Journal of biological chemistry - 30 Nov 2007

Bourhis Eric, Hymowitz Sarah G, Cochran Andrea G

Abstract excerpt

Survivin is a member of the IAP (inhibitor of apoptosis) protein family, defined in part by the presence of a zinc-binding baculoviral inhibitory repeat (BIR) domain. Most BIR domains bind short sequences beginning with alanine, and in this manner, they recognize and block the action of key targets in apoptotic pathways. However, Survivin binds only very weakly to typical IAP ligands. Unique features of Survivin...

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Source

Identifiers

PMID: 17881355
DOI: 10.1074/jbc.M706233200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The mitotic regulator Survivin binds as a monomer to its functional interactor Borealin.PMID 17881355Read ↗

Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together.Semantic proximity Read ↗

Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement.Semantic proximity Read ↗

Survivin mutant (Surv-DD70, 71AA) disrupts the interaction of Survivin with Aurora B and causes multinucleation in HeLa cells.Semantic proximity Read ↗

Small-Molecule Intervention At The Dimerization Interface Of Survivin By Novel Rigidized Scaffolds.Semantic proximity Read ↗

The chromosomal passenger complex: one for all and all for one.Semantic proximity Read ↗

Molecular analysis of survivin isoforms: evidence that alternatively spliced variants do not play a role in mitosis.Semantic proximity Read ↗

Crystal Structure of Human Survivin Reveals a Bow Tie–Shaped Dimer with Two Unusual α-Helical ExtensionsSemantic proximity Read ↗

Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle.Semantic proximity Read ↗

Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype.Semantic proximity Read ↗

Threonine 48 in the BIR domain of survivin is critical to its mitotic and anti-apoptotic activities and can be phosphorylated by CK2 in vitro.Semantic proximity Read ↗

An IAP in Action: The Multiple Roles of Survivin in Differentiation, Immunity and MalignancySemantic proximity Read ↗

INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis.Semantic proximity Read ↗

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