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Article

The chromosomal passenger complex: one for all and all for one.

Cell - 19 Oct 2007

Ruchaud Sandrine, Carmena Mar, Earnshaw William C

Abstract excerpt

The chromosomal passenger complex-composed of Aurora B kinase and its regulatory subunits INCENP, Survivin, and Borealin-modulates multiple events during mitosis. In this issue, Jeyaprakash et al. (2007) report the crystal structure of the regulatory subunit complex and reveal how interactions between these proteins promote the targeting and function of the chromosomal passenger complex during mitosis.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17956723
DOI: 10.1016/j.cell.2007.10.002

Genes

INCENP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The chromosomal passenger complex: one for all and all for one.PMID 17956723Read ↗

Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together.Semantic proximity Read ↗

Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle.Semantic proximity Read ↗

Dynamic localization of the chromosomal passenger complex in trypanosomes is controlled by the orphan kinesins KIN-A and KIN-BSemantic proximity Read ↗

Australin: a chromosomal passenger protein required specifically for Drosophila melanogaster male meiosis.Semantic proximity Read ↗

Aurora B kinase activity–dependent and –independent functions of the chromosomal passenger complex in regulating sister chromatid cohesionSemantic proximity Read ↗

The Inner Centromere Protein (INCENP) Coil Is a Single α-Helix (SAH) Domain That Binds Directly to Microtubules and Is Important for Chromosome Passenger Complex (CPC) Localization and Function in Mitosis.Semantic proximity Read ↗

Development of a Chemical Genetic Approach for Human Aurora B Kinase Identifies Novel Substrates of the Chromosomal Passenger ComplexSemantic proximity Read ↗

Gradient of increasing Aurora B kinase activity is required for cells to execute mitosis.Semantic proximity Read ↗

The chromosomal passenger complex controls the function of endosomal sorting complex required for transport-III Snf7 proteins during cytokinesis.Semantic proximity Read ↗

The chromosome passenger complex is required for fidelity of chromosome transmission and cytokinesis in meiosis of mouse oocytes.Semantic proximity Read ↗

The mitotic regulator Survivin binds as a monomer to its functional interactor Borealin.Semantic proximity Read ↗

Loss of Drosophila borealin causes polyploidy, delayed apoptosis and abnormal tissue development.Semantic proximity Read ↗

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