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Article

Small-Molecule Intervention At The Dimerization Interface Of Survivin By Novel Rigidized Scaffolds.

Drug design, development and therapy - 1 Jan 2019

Ibrahim Tamer M, Ernst Christoph, Lange Andreas, Hennig Susanne, Boeckler Frank M

Abstract excerpt

INTRODUCTION: Survivin is a nodal protein involved in several cellular pathways. It is a member of the IAP family and an integral component of the chromosomal passenger complex, where it binds to borealin and INCENP through its dimerization interface. By targeting survivin with a small molecule at its dimerization interface, inhibition of the proliferation of cancer cells has been suggested. With Abbott 8, a...

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Identifiers

PMID: 31908412
DOI: 10.2147/DDDT.S224561
PMCID: PMC6927794

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