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Article

Molecular analysis of survivin isoforms: evidence that alternatively spliced variants do not play a role in mitosis.

The Journal of biological chemistry - 13 Jan 2006

Noton Elizabeth A, Colnaghi Rita, Tate Sharon, Starck Carlene, Carvalho Ana, Ko Ferrigno Paul, Wheatley Sally P

Abstract excerpt

Survivin is a protein with proposed roles in cell division and apoptosis. Transcripts encoding splice variants of human survivin have been described and their expression correlated with cancer progression. As survivin forms homodimers in vitro, it has been suggested that these isoforms could interfere with wild type function by forming heterodimers. Here we show that survivin-2beta and survivin-deltaEx3 can...

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Source

Identifiers

PMID: 16291752
DOI: 10.1074/jbc.M508773200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Molecular analysis of survivin isoforms: evidence that alternatively spliced variants do not play a role in mitosis.PMID 16291752Read ↗

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Survivin study: an update of "what is the next wave"?Semantic proximity Read ↗

The mitotic regulator Survivin binds as a monomer to its functional interactor Borealin.Semantic proximity Read ↗

Survivin: Role in Normal Cells and in Pathological ConditionsSemantic proximity Read ↗

Nucleocytoplasmic shuttling and the biological activity of mouse survivin are regulated by an active nuclear export signal.Semantic proximity Read ↗

Distinct <i>in vivo</i> expression patterns of survivin splice variants in renal cell carcinomasSemantic proximity Read ↗

Cell division and cell survival in the absence of survivinSemantic proximity Read ↗

Separating the anti-apoptotic and mitotic roles of survivin.Semantic proximity Read ↗

Survivin, Survivin-2B, and Survivin-deItaEx3 expression in medulloblastoma: biologic markers of tumour morphology and clinical outcomeSemantic proximity Read ↗

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