Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Homophilic Dscam interactions control complex dendrite morphogenesis.

Neuron - 3 May 2007

Hughes Michael E, Bortnick Rachel, Tsubouchi Asako, Bäumer Philipp, Kondo Masahiro, Uemura Tadashi, Schmucker Dietmar

Abstract excerpt

Alternative splicing of the Drosophila gene Dscam results in up to 38,016 different receptor isoforms proposed to interact by isoform-specific homophilic binding. We report that Dscam controls cell-intrinsic aspects of dendrite guidance in all four classes of dendrite arborization (da) neurons. Loss of Dscam in single neurons causes a strong increase in self-crossing. Restriction of dendritic fields of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Cell Adhesion Molecules

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Communication

Share to Dendrites

Share to Drosophila

Share to Embryo, Nonmammalian

Share to Morphogenesis

Share to Protein Isoforms

Source

Open in PubMed Open full text

Identifiers

PMID: 17481395
DOI: 10.1016/j.neuron.2007.04.013
PMCID: PMC1963440

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Homophilic Dscam interactions control complex dendrite morphogenesis.PMID 17481395Read ↗

Cell-intrinsic requirement of Dscam1 isoform diversity for axon collateral formation.Semantic proximity Read ↗

Drosophila sensory neurons require Dscam for dendritic self-avoidance and proper dendritic field organization.Semantic proximity Read ↗

Generation of recognition diversity in the nervous system.Semantic proximity Read ↗

The molecular diversity of Dscam is functionally required for neuronal wiring specificity in Drosophila.Semantic proximity Read ↗

Complementary chimeric isoforms reveal Dscam1 binding specificity in vivo.Semantic proximity Read ↗

Robust discrimination between self and non-self neurites requires thousands of Dscam1 isoforms.Semantic proximity Read ↗

Dscam diversity is essential for neuronal wiring and self-recognition.Semantic proximity Read ↗

Cell autonomy of DSCAM function in retinal development.Semantic proximity Read ↗

Dscam Proteins Direct Dendritic Targeting through Adhesion.Semantic proximity Read ↗

Tyrosine phosphorylation is essential for DSCAML1 to promote dendrite arborization of mouse cortical neurons.Semantic proximity Read ↗

Stochastic yet biased expression of multiple Dscam splice variants by individual cells.Semantic proximity Read ↗

Specific Drosophila Dscam juxtamembrane variants control dendritic elaboration and axonal arborization.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.