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Article

Loss of heterozygosity at 19p13.2 and 2q21 in tumours from familial clusters of non-medullary thyroid carcinoma.

Familial cancer - 1 Jan 2008

Prazeres Hugo João, Rodrigues Fernando, Soares Paula, Naidenov Plamen, Figueiredo Paulo, Campos Beatriz, Lacerda Manuela, Martins Teresa C

Abstract excerpt

Linkage studies have identified susceptibility loci for familial nonmedullary thyroid cancer (FNMTC), with and without cell oxyphilia, at chromosomal regions 19p13.2 and 2q21. There are few genetic analyses of FNMTC tumours reported at the present time and the eventual gene involved was not identified yet. The aim of this study was to assess the occurrence of loss of heterozygosity (LOH) at these loci in the...

Topics

Adolescent
Adult
Alleles
Chromosomes, Human, Pair 19
Female
Genes, Tumor Suppressor
Genotype
Humans
Loss of Heterozygosity
Male
Microsatellite Repeats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Multigene Family

Risk Factors

Thyroid Neoplasms

Source

Identifiers

PMID: 17823852
DOI: 10.1007/s10689-007-9160-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Loss of heterozygosity at 19p13.2 and 2q21 in tumours from familial clusters of non-medullary thyroid carcinoma.PMID 17823852Read ↗

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