Article
The FOXE1 locus is a major genetic determinant for familial nonmedullary thyroid carcinoma.
International journal of cancer - 1 May 2014
Bonora Elena, Rizzato Cosmeri, Diquigiovanni Chiara, Oudot-Mellakh Tiphaine, Campa Daniele, Vargiolu Manuela, Guedj Mickaël, McKay James D, Romeo Giovanni, Canzian Federico, Lesueur Fabienne
Abstract excerpt
Thyroid cancer is the most common endocrine malignancy and nonmedullary thyroid carcinoma (NMTC) represents 90% of all cases. NMTC risk in first-degree relatives of affected cases is elevated fivefold to ninefold. Familial NMTC (FNMTC) accounts for about 3-7% of all thyroid tumors and is a more aggressive clinical entity than its sporadic counterparts. Linkage analysis on high-risk families performed a decade ago...
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