Article
Localization of a susceptibility gene for familial nonmedullary thyroid carcinoma to chromosome 2q21.
American journal of human genetics - 1 Aug 2001
McKay J D, Lesueur F, Jonard L, Pastore A, Williamson J, Hoffman L, Burgess J, Duffield A, Papotti M, Stark M, Sobol H, Maes B, Murat A, Kääriäinen H, Bertholon-Grégoire M, Zini M, Rossing M A, Toubert M E, Bonichon F, Cavarec M, Bernard A M, Boneu A, Leprat F, Haas O, Lasset C, Schlumberger M, Canzian F, Goldgar D E, Romeo G
Abstract excerpt
The familial form of nonmedullary thyroid carcinoma (NMTC) is a complex genetic disorder characterized by multifocal neoplasia and a higher degree of aggressiveness than its sporadic counterpart. In a large Tasmanian pedigree (Tas1) with recurrence of papillary thyroid carcinoma (PTC), the most common form of NMTC, an extensive genomewide scan revealed a common haplotype on chromosome 2q21 in seven of the eight...
Topics
- Carcinoma, Papillary
- Chromosome Mapping
- Chromosomes, Human, Pair 2
- DNA-Binding Proteins
- Female
- Genetic Heterogeneity
- Genetic Predisposition to Disease
- Goiter