Article
Genetic events in tumour initiation and progression in multiple endocrine neoplasia type 2.
Genes, chromosomes & cancer - 1 Mar 1993
Mulligan L M, Gardner E, Smith B A, Mathew C G, Ponder B A
Abstract excerpt
Multiple endocrine neoplasia type 2 (MEN 2) is a familial cancer syndrome arising from mutation at a locus or loci in chromosome region 10p11.2-q11.2. The disease is characterized by medullary thyroid carcinoma (MTC) and pheochromocytoma (Pheo). To assess the genetic events in tumour initiation and progression in this disease, we have compiled an allelotype for MTC and Pheo tumours using polymorphic marker loci...
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