Article
Mapping a new familial thyroid epithelial neoplasia susceptibility locus to chromosome 8p23.1-p22 by high-density single-nucleotide polymorphism genome-wide linkage analysis.
The Journal of clinical endocrinology and metabolism - 1 Nov 2008
Cavaco Branca M, Batista Pedro F, Sobrinho Luís G, Leite Valeriano
Abstract excerpt
CONTEXT: Familial nonmedullary thyroid carcinoma (FNMTC) accounts for approximately 5% of all thyroid tumors. Genetic mapping studies have identified four different chromosomal regions predisposing to FNMTC: fPTC/PRN (1p13.2-1q22), NMTC1 (2q21), MNG1 (14q32), and TCO (19p13.2). OBJECTIVE: Our objective was to map the gene predisposing to familial thyroid epithelial neoplasia in a large Portuguese family. METHODS...
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