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Article

Conditional deletion of gremlin causes a transient increase in bone formation and bone mass.

The Journal of biological chemistry - 26 Oct 2007

Gazzerro Elisabetta, Smerdel-Ramoya Anna, Zanotti Stefano, Stadmeyer Lisa, Durant Deena, Economides Aris N, Canalis Ernesto

Abstract excerpt

Gremlin is a glycoprotein that binds bone morphogenetic proteins (BMPs) 2, 4, and 7, antagonizing their actions. Gremlin opposes BMP effects on osteoblastic differentiation and function in vitro and in vivo, and its overexpression causes osteopenia. To define the function of gremlin in the skeleton, we generated gremlin 1 (grem1) conditional null mice by mating mice where grem1 was flanked by lox(P) sequences...

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Identifiers

PMID: 17785465
DOI: 10.1074/jbc.M701317200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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