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Article

Skeletal overexpression of gremlin impairs bone formation and causes osteopenia.

Endocrinology - 1 Feb 2005

Gazzerro Elisabetta, Pereira Renata C, Jorgetti Vanda, Olson Sarah, Economides Aris N, Canalis Ernesto

Abstract excerpt

Skeletal cells synthesize bone morphogenetic proteins (BMPs) and BMP antagonists. Gremlin, a BMP antagonist, is expressed in osteoblasts and opposes BMP effects on osteoblastic differentiation and function in vitro. However, its effects in vivo are not known. To investigate the actions of gremlin on bone remodeling in vivo, we generated transgenic mice overexpressing gremlin under the control of the osteocalcin...

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Identifiers

PMID: 15539560
DOI: 10.1210/en.2004-0766

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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