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Increased BMP-Smad signaling does not affect net bone mass in long bones

30 Mar 2023

Abstract excerpt

Bone morphogenetic proteins (BMPs) have been used for orthopedic and dental application due to their osteoinductive properties; however, substantial numbers of adverse reactions such as heterotopic bone formation, increased bone resorption and greater cancer risk have been reported. Since bone morphogenetic proteins signaling exerts pleiotropic effects on various tissues, it is crucial to understand...

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PMID: 37064883
DOI: 10.3389/fphys.2023.1145763

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