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Article

Increased trabecular bone and improved biomechanics in an osteocalcin-null rat model created by CRISPR/Cas9 technology.

Disease models & mechanisms - 1 Oct 2016

Lambert Laura J, Challa Anil K, Niu Aidi, Zhou Lihua, Tucholski Janusz, Johnson Maria S, Nagy Tim R, Eberhardt Alan W, Estep Patrick N, Kesterson Robert A, Grams Jayleen M

Abstract excerpt

Osteocalcin, also known as bone γ-carboxyglutamate protein (Bglap), is expressed by osteoblasts and is commonly used as a clinical marker of bone turnover. A mouse model of osteocalcin deficiency has implicated osteocalcin as a mediator of changes to the skeleton, endocrine system, reproductive organs and central nervous system. However, differences between mouse and human osteocalcin at both the genome and...

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Identifiers

PMID: 27483347
DOI: 10.1242/dmm.025247
PMCID: PMC5087831

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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