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Article

Overexpression of GαS in Murine Osteoblasts In Vivo Leads to Increased Bone Mass and Decreased Bone Quality.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Nov 2017

Zhang Lucia, Sugamori Kim S, Claridge Colin, Dela Cruz Ariana, Grynpas Marc D, Mitchell Jane

Abstract excerpt

GαS is a heterotrimeric G protein that transduces signals from activated G protein-coupled receptors on the cell surface to stimulate adenylyl cyclase/cyclic adenosine monophosphate (AMP) signaling. GαS plays a central role in mediating numerous growth and maintenance processes including osteogenesis and bone turnover. Decreased GαS expression or activating mutations in GαS both affect bone, suggesting that...

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Identifiers

PMID: 28727179
DOI: 10.1002/jbmr.3223

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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