Article
Transplantation resistance to a murine plasmacytoma lacking MHC determinants.
Cellular immunology - 15 Apr 1990
Daley M J, Williams T J, Giorgi J, Warner N L
Abstract excerpt
A spontaneously arising murine plasmacytoma, HPC-202, derived from a BALB/c.H-2b congenic mouse that lacks any detectable H-2 determinants on its cell surface is described. However, the expression of H-2 determinants is inducible by interferon-gamma. The H-2 negative cell surface phenotype permits the HPC-202 tumor to escape H-2 allospecific cytotoxic cell lysis but not NK cell lysis, as well as to grow, to...
Topics
- Animals
- Antigens, Surface
- Cytotoxicity, Immunologic
- Epitopes
- Female
- Gene Expression Regulation, Neoplastic
- Genes, MHC Class I
- Genes, Recessive
- Graft vs Host Reaction
- Major Histocompatibility Complex
- Male
