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Article

Anthrax protective antigen cleavage and clearance from the blood of mice and rats.

Infection and immunity - 1 Nov 2007

Moayeri Mahtab, Wiggins Jason F, Leppla Stephen H

Abstract excerpt

Bacillus anthracis protective antigen (PA) is an 83-kDa (PA83) protein that is cleaved to the 63-kDa protein (PA63) as an essential step in binding and internalizing lethal factor (LF). To assess in vivo receptor saturating PA concentrations, we injected mice with PA variants and measured the PA remaining in the blood at various times using PA83- and PA63-specific enzyme-linked immunosorbent assays. We found that...

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Identifiers

PMID: 17724066
DOI: 10.1128/IAI.00719-07
PMCID: PMC2168306

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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