Article
Mapping the anthrax protective antigen binding site on the lethal and edema factors.
The Journal of biological chemistry - 25 Jan 2002
Lacy D Borden, Mourez Michael, Fouassier Alexandre, Collier R John
Abstract excerpt
Entry of anthrax edema factor (EF) and lethal factor (LF) into the cytosol of eukaryotic cells depends on their ability to translocate across the endosomal membrane in the presence of anthrax protective antigen (PA). Here we report attributes of the N-terminal domains of EF and LF (EF(N) and LF(N), respectively) that are critical for their initial interaction with PA. We found that deletion of the first 36...
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