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Article

Case control analysis of LRRK2 Gly2385Arg in Alzheimer's disease.

Neurobiology of aging - 1 Mar 2009

Tan E K, Lee J, Chen C P, Wong M C, Zhao Y

Abstract excerpt

Alzheimer's disease (AD) pathology has been described in Parkinson's disease (PD) patients with leucine-rich repeat kinase-2 (LRRK2) mutations. A common LRRK2 Gly2385Arg variant has been widely shown to be associated with a twofold increased risk of PD in various Asian populations. In a case control study, the frequency of the heterozygous Gly2385Arg genotype was demonstrated in 4.3% of AD compared to 4.5% in...

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Identifiers

PMID: 17720280
DOI: 10.1016/j.neurobiolaging.2007.07.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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