Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

LRRK2 variant associated with Alzheimer's disease.

Neurobiology of aging - 1 Nov 2011

Zhao Yi, Ho P, Yih Yuen, Chen C, Lee W L, Tan E K

Abstract excerpt

Overlapping neurodegenerative pathologies (including Alzheimer's disease, AD) have been described in Parkinson's disease (PD) patients with leucine-rich repeat kinase-2 (LRRK2) mutations. We analyzed a LRRK2 PD (R1628P) risk variant in a group of 885 subjects comprising of AD and controls. The frequency of the R1628P allele was higher in AD compared to controls (3.5% vs. 1.6%, OR 2.3, 95 CI 1.2-4.4, p=0.018). In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Apoptosis
Share to Cells, Cultured

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Association Studies

Share to Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Share to Parkinson Disease

Share to Protein Serine-Threonine Kinases

Share to Transfection

Source

Identifiers

PMID: 20018409
DOI: 10.1016/j.neurobiolaging.2009.11.019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

LRRK2 variant associated with Alzheimer's disease.PMID 20018409Read ↗

The association between the LRRK2 R1628P variant and the risk of Parkinson's disease in Asian: a meta-analysis.Semantic proximity Read ↗

LRRK2 R1628P increases risk of Parkinson's disease: replication evidence.Semantic proximity Read ↗

Identification of a common genetic risk variant (LRRK2 Gly2385Arg) in Parkinson's disease.Semantic proximity Read ↗

The LRRK2 R1628P variant plays a protective role in Han Chinese population with Alzheimer's disease.Semantic proximity Read ↗

The LRRK2 Gly2385Arg variant is associated with Parkinson's disease: genetic and functional evidence.Semantic proximity Read ↗

Relationship between LRRK2 R1628P polymorphism and Parkinson's disease in Asian populations.Semantic proximity Read ↗

Molecular biology changes associated with LRRK2 mutations in Parkinson's disease.Semantic proximity Read ↗

LRRK2 R1628P variant is a risk factor of Parkinson's disease among Han-Chinese from mainland China.Semantic proximity Read ↗

LRRK2 R1628P contributes to Parkinson's disease susceptibility in Chinese Han populations from mainland China.Semantic proximity Read ↗

The Parkinson Disease Protein Leucine-Rich Repeat Kinase 2 Transduces Death Signals via Fas-Associated Protein with Death Domain and Caspase-8 in a Cellular Model of NeurodegenerationSemantic proximity Read ↗

Activation of FADD-Dependent Neuronal Death Pathways as a Predictor of Pathogenicity for LRRK2 Mutations.Semantic proximity Read ↗

Confirmation of the association between LRRK2 R1628P variant and susceptibility to Parkinson's disease in the Thai population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.