Article
Leucine-rich repeat kinase 2 (LRRK2) mutations in a Swedish Parkinson cohort and a healthy nonagenarian.
Movement disorders : official journal of the Movement Disorder Society - 1 Oct 2006
Carmine Belin Andrea, Westerlund Marie, Sydow Olof, Lundströmer Karin, Håkansson Anna, Nissbrandt Hans, Olson Lars, Galter Dagmar
Abstract excerpt
Specific variants of Leucine-rich repeat kinase 2 (LRRK2) have been shown to associate with Parkinson's disease (PD). Several mutations have been found in PD populations from different parts of the world. We investigated the occurrence of three mutations (R1441G/C/H, G2019S, and I2020T) in our Swedish case-control material and identified four carriers of the G2019S mutation in 284 PD cases and 1 95-year-old...
Topics
- Adult
- Aged
- Aged, 80 and over
- Case-Control Studies
- Cohort Studies
- Female
- Genetic Carrier Screening
- Genetic Variation
- Genetics, Population
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Male
- Middle Aged