Article
LRRK2 Gly2385Arg variant is a risk factor of Parkinson's disease among Han-Chinese from mainland China.
European journal of neurology - 1 Mar 2008
An X-K, Peng R, Li T, Burgunder J-M, Wu Y, Chen W-J, Zhang J-H, Wang Y-C, Xu Y-M, Gou Y-R, Yuan G-G, Zhang Z-J
Abstract excerpt
Mutations in the gene encoding Leucine-rich repeat kinase 2 (LRRK2) have been recently linked with autosomal-dominant parkinsonism, and polymorphisms have been commonly associated with sporadic Parkinson's disease (PD). A p.2385G>R variant has been reported as a risk factor for PD in Taiwan, Singapore and Japan. Herein, we have assessed the frequency of this polymorphism among the ethnic Han-Chinese population in...
Topics
- Adult
- Aged
- Aged, 80 and over
- Arginine
- Asian People
- Chi-Square Distribution
- China
- Female
- Genetic Predisposition to Disease
- Genotype
- Glycine
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2