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Article

Case-control analysis of leucine-rich repeat kinase 2 protective variants in Alzheimer's disease.

Neurobiology of aging - 1 Apr 2018

Ng Adeline S L, Ng Ebonne Y L, Tan Yi Jayne, Kandiah Nagaendran, Zhou Juan, Hameed Shahul, Ting Simon K S, Tan Eng-King

Abstract excerpt

Amyloid is the main pathological substrate of Alzheimer's disease (AD) and has been described in leucine-rich repeat kinase 2 (LRRK2) carriers with Parkinson's disease. LRRK2 has been linked with amyloid precursor protein pathways in neurodegeneration. Two common LRRK2 variants, R1398H and N551K, have been shown to be protective in multiple Parkinson's disease cohorts. We hypothesized that R1398H and N551K may be...

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Identifiers

PMID: 29241968
DOI: 10.1016/j.neurobiolaging.2017.11.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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