Article
A common missense variant in the LRRK2 gene, Gly2385Arg, associated with Parkinson's disease risk in Taiwan.
Neurogenetics - 1 Jul 2006
Di Fonzo Alessio, Wu-Chou Yah-Huei, Lu Chin-Song, van Doeselaar Marina, Simons Erik J, Rohé Christan F, Chang Hsiu-Chen, Chen Rou-Shayn, Weng Yi-Hsin, Vanacore Nicola, Breedveld Guido J, Oostra Ben A, Bonifati Vincenzo
Abstract excerpt
Mutations in the LRRK2 gene are a cause of autosomal dominant Parkinson's disease (PD). Whether LRRK2 variants influence susceptibility to the commoner, sporadic forms of PD remains largely unknown. Data are particularly limited concerning the Asian population. In search for novel, biologically relevant variants, we sequenced the LRRK2 coding region in Taiwanese patients with PD. Four newly identified variants...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Amino Acid Sequence
- Case-Control Studies
- Child
- DNA Mutational Analysis
- Female
- Gene Frequency