Article
Discovery of common human genetic variants of GTP cyclohydrolase 1 (GCH1) governing nitric oxide, autonomic activity, and cardiovascular risk.
The Journal of clinical investigation - 1 Sept 2007
Zhang Lian, Rao Fangwen, Zhang Kuixing, Khandrika Srikrishna, Das Madhusudan, Vaingankar Sucheta M, Bao Xuping, Rana Brinda K, Smith Douglas W, Wessel Jennifer, Salem Rany M, Rodriguez-Flores Juan L, Mahata Sushil K, Schork Nicholas J, Ziegler Michael G, O'Connor Daniel T
Abstract excerpt
GTP cyclohydrolase 1 (GCH1) is rate limiting in the provision of the cofactor tetrahydrobiopterin for biosynthesis of catecholamines and NO. We asked whether common genetic variation at GCH1 alters transmitter synthesis and predisposes to disease. Here we undertook a systematic search for polymorphisms in GCH1, then tested variants' contributions to NO and catecholamine release as well as autonomic function in...
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