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Article

GTP cyclohydroxylase1 (GCH1): Role in neurodegenerative diseases.

Gene - 20 Dec 2023

Gupta Parul, Kumar Ravindra

Abstract excerpt

GCH1 gene provides directions for the synthesis of GTP cyclohydrolase 1 which regulates the formation of Tetrahydrobiopterin (BH4). BH4 is a crucial cofactor for essential neurotransmitters synthesis such as dopamine, serotonin and nitric oxide synthases. Deficiency of GCH1 limits the synthesis of BH4 which is responsible for neuropsychiatric diseases such as dopa-responsive dystonia, hyperalaninemia, Parkinson's...

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Identifiers

PMID: 37652170
DOI: 10.1016/j.gene.2023.147749

Genes

GCH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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GTP cyclohydroxylase1 (GCH1): Role in neurodegenerative diseases.PMID 37652170Read ↗

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