Phenotypic Consequences of a Genetic Predisposition to Enhanced Nitric Oxide Signaling.

doi:10.1161/CIRCULATIONAHA.117.028021

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Article

Phenotypic Consequences of a Genetic Predisposition to Enhanced Nitric Oxide Signaling.

Circulation - 16 Jan 2018

Emdin Connor A, Khera Amit V, Klarin Derek, Natarajan Pradeep, Zekavat Seyedeh M, Nomura Akihiro, Haas Mary, Aragam Krishna, Ardissino Diego, Wilson James G, Schunkert Heribert, McPherson Ruth, Watkins Hugh, Elosua Roberto, Bown Matthew J, Samani Nilesh J, Baber Usman, Erdmann Jeanette, Gormley Padhraig, Palotie Aarno, Stitziel Nathan O, Gupta Namrata, Danesh John, Saleheen Danish, Gabriel Stacey, Kathiresan Sekar

Abstract excerpt

BACKGROUND: Nitric oxide signaling plays a key role in the regulation of vascular tone and platelet activation. Here, we seek to understand the impact of a genetic predisposition to enhanced nitric oxide signaling on risk for cardiovascular diseases, thus informing the potential utility of pharmacological stimulation of the nitric oxide pathway as a therapeutic strategy. METHODS: We analyzed the association of...

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PMID: 28982690
DOI: 10.1161/CIRCULATIONAHA.117.028021
PMCID: PMC5771958

Genes

NOS3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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