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Article

GTP cyclohydrolase I gene polymorphisms are associated with endothelial dysfunction and oxidative stress in patients with type 2 diabetes mellitus.

PloS one - 1 Jan 2014

Wolkow Pawel P, Kosiniak-Kamysz Wladyslaw, Osmenda Grzegorz, Wilk Grzegorz, Bujak-Gizycka Beata, Ignacak Adam, Kanitkar Mihir, Walus-Miarka Malgorzata, Harrison David G, Korbut Ryszard, Malecki Maciej T, Guzik Tomasz J

Abstract excerpt

BACKGROUND: The genetic background of atherosclerosis in type 2 diabetes mellitus (T2DM) is complex and poorly understood. Studying genetic components of intermediate phenotypes, such as endothelial dysfunction and oxidative stress, may aid in identifying novel genetic components for atherosclerosis in diabetic patients. METHODS: Five polymorphisms forming two haplotype blocks within the GTP cyclohydrolase 1...

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Identifiers

PMID: 25369080
DOI: 10.1371/journal.pone.0108587
PMCID: PMC4219671

Genes

GCH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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