Article
GCH1 plays a role in the high-altitude adaptation of Tibetans.
Zoological research - 18 May 2017
Guo Yong-Bo, He Yao-Xi, Cui Chao-Ying, Ouzhu Luobu, Baima Kangzhuo, Duoji Zhuoma, Deji Quzong, Bian Ba, Peng Yi, Bai Cai-Juan, Gongga Lanzi, Pan Yong-Yue, Qu la, Kang Min, Ciren Yangji, Baima Yangji, Guo Wei, Yang la, Zhang Hui, Zhang Xiao-Ming, Zheng Wang-Shan, Xu Shu-Hua, Chen Hua, Zhao Sheng-Guo, Cai Yuan, Liu Shi-Ming, Wu Tian-Yi, Qi Xue-Bin, Su Bing
Abstract excerpt
Tibetans are well adapted to high-altitude hypoxia. Previous genome-wide scans have reported many candidate genes for this adaptation, but only a few have been studied. Here we report on a hypoxia gene ( GCH1, GTP-cyclohydrolase I), involved in maintaining nitric oxide synthetase (NOS) function and normal blood pressure, that harbors many potentially adaptive variants in Tibetans. We resequenced an 80.8 kb...
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