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Article

Importance of constitutive activity and arrestin-independent mechanisms for intracellular trafficking of the ghrelin receptor.

Molecular endocrinology (Baltimore, Md.) - 1 Dec 2007

Holliday Nicholas D, Holst Birgitte, Rodionova Elena A, Schwartz Thue W, Cox Helen M

Abstract excerpt

The ghrelin receptor (GhrelinR) and its related orphan GPR39 each display constitutive signaling, but only GhrelinRs undergo basal internalization. Here we investigate these differences by considering the roles of the C tail receptor domains for constitutive internalization and activity. Furthermore the interaction between phosphorylated receptors and beta-arrestin adaptor proteins has been examined. Replacement...

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Source

Identifiers

PMID: 17717076
DOI: 10.1210/me.2007-0254

Genes

GPR39

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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