Article

<i>In vitro</i> profiling of orphan G protein coupled receptor (GPCR) constitutive activity

2021-03-11

Abstract excerpt

<h4>Background and Purpose</h4> Members of the G protein coupled receptor (GPCR) family are targeted by a significant fraction of the available FDA-approved drugs. However, the physiological role and pharmacological properties of many GPCRs remain unknown, representing untapped potential in drug design. Of particular interest are ~100 less-studied GPCRs known as orphans because their endogenous ligands are unknow...

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Literature Corpus work: 59538a4e-c07b-5817-ac66-e1069285c641
DOI: 10.1101/2021.03.10.434788

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