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Article

Ligand-induced internalization and recycling of the human neuropeptide Y2 receptor is regulated by its carboxyl-terminal tail.

The Journal of biological chemistry - 31 Dec 2010

Walther Cornelia, Nagel Stefanie, Gimenez Luis E, Mörl Karin, Gurevich Vsevolod V, Beck-Sickinger Annette G

Abstract excerpt

Agonist-induced internalization of G protein-coupled receptors plays an important role in signal regulation. The underlying mechanisms of the internalization of the human neuropeptide Y(2) receptor (hY(2)R), as well as its desensitization, endocytosis, and resensitization are mainly unknown. In the present study we have investigated the role of carboxyl-terminal (C-terminal) Ser/Thr residues and acidic amino...

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Identifiers

PMID: 20959467
DOI: 10.1074/jbc.M110.162156
PMCID: PMC3009885

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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